Congratulations
to Dr. Eleftheria Letsiou for being the recipient of one of the three
Hermann Rahn awards for 2015. Dr. Letsiou is a postdoctoral research
associate in the Division of Medicine
(Pulmonary, Critical Care, Sleep and Allergy) at the University of
Illinois at Chicago. She was nominated by her mentor Dr. Steven M.
Dudek for her paper
Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury.
Am J Physiol Lung Cell Mol Physiol.
2015 Feb 1;308(3):L259-69, PMID: 25480336. Eleftheria utilized
preclinical mouse models to demonstrate
that imatinib (an FDA-approved Abl kinases inhibitor) protects against
endotoxin-induced ALI, but it conversely exacerbates ventilator-induced
lung injury (VILI).
this study is the first to demonstrate Abl inhibition by imatinib
exerts both endothelial barrier protection and anti-inflammatory
effects in murine ALI.
Sadis Matalon, Ph.D., Dr.Sc. (Hon.)
Editor-in-Chief
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