Congratulations to Dr. Eleftheria Letsiou for being the recipient of one of the three Hermann Rahn awards for 2015. Dr. Letsiou is a postdoctoral research associate in the Division of Medicine (Pulmonary, Critical Care, Sleep and Allergy) at the University of Illinois at Chicago. She was nominated by her mentor Dr. Steven M. Dudek for her paper Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L259-69, PMID: 25480336. Eleftheria utilized preclinical mouse models to demonstrate that imatinib (an FDA-approved Abl kinases inhibitor) protects against endotoxin-induced ALI, but it conversely exacerbates ventilator-induced lung injury (VILI). this study is the first to demonstrate Abl inhibition by imatinib exerts both endothelial barrier protection and anti-inflammatory effects in murine ALI.
Sadis Matalon, Ph.D., Dr.Sc. (Hon.)