Monday, April 24, 2017

Congratulations to the 2016 Paper of the Year Award Winners


It is with great pleasure that we announce the 2016 winners of AJP-Lung's Paper of the Year.  Each will receive $500 and Certificate.

Best Research Paper by a Junior Investigator 

 Dr. Roman Grothausmann

 Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L243-L257. Epub 2016 Dec 2. Digital 3Dreconstructions using histological serial sections of lung tissue including thealveolar capillary network. Grothausmann, R., Knudsen L, Ochs M, Mühlfeld C); PMID: 27913424

 

 

Best Research Paper by a Senior Investigator

 Dr. Dean Sheppard

         Am J Physiol Lung Cell Mol Physiol. January 1, 2017 DOI: 10.1152/ajplung.00428.2016. Transforming growth factor-β playsdivergent roles in modulating vascular remodeling, inflammation, and pulmonaryfibrosis in a murine model of scleroderma.Kazuyuki Tsujino, Nilgun Isik Reed, Amha Atakilit, Xin Ren, Dean Sheppard

 

 

AJP-Lung Highlights of 2016 Presentation

Please see the updated PowerPoint Presentation below, We are proud of our accomplishments made in the past year at AJP-Lung...

Matalon PPTX Experimental Bio 2017 to Be Posted in Web[1] by ajplung on Scribd

Friday, April 14, 2017

AJP-Lung first quarter submissions are up!

We just received our first quarter numbers for 2017 and are pleased to tell you that AJP-Lung had a 7% increase in submissions over our 1st quarter 2016 (which was our banner year).  Please keep submitting your best work to us!

Tuesday, April 11, 2017

AJP-Lung Highlights of 2016

Dr. Matalon presented the following highlights of AJP-Lung at the Publications meeting in March 2017.  We are very proud to share them with you.




AJP-Lung Matalon 3-21-2017 by ajplung on Scribd

Monday, March 6, 2017

APS Select March 2017

Congratulations go to Dr, Palumbo and collelagues for their recent pick as an APS Select paper for March 2017.

You can read this important paper here :

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Monday, February 13, 2017

Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and non-asthmatics

Airway remodeling is a cardinal feature of diseases such as asthma. Previous measurements and modeling of the airways of non-asthmatics vs. asthmatics have shown that increased airway smooth muscle contributes substantially to remodeling and the resultant narrowing of the airway lumen. However, the assumption in models based on lung morphometry is that narrowing occurs proportionately, i.e. homogenously along the branches of the bronchial tree. In this elegant modeling paper based on measurements of airway lumens from asthmatics vs. non-asthmatics, Pascoe et al. demonstrate for the first time that there is profound heterogeneity in the extent of remodeling along the different branches of the bronchial tree, with small airways contributing particularly to such heterogeneity. The predicted physiological importance of this heterogeneity in airwaywall dimensions of non-asthmatics and asthmatics lies in their contribution to airway hyperresponsiveness (the model predicting a leftward shift in the likely dose response to bronchoconstrictor agonist). Here, closure of small airways is predicted, as is known to occur in obstructive airway disease. However, what is interesting is that a disproportionate or greater heterogeneity in asthmatic airways does not necessarily predict AHR, but it is the increase in airway wall dimensions that does. The appeal of such elegant modeling studies in human lungs of asthmatics vs. non-asthmatics lies in emphasizing the need for more mechanistic studies on remodeling, particularly of the small airways that contribute to premature closure and obstructive disease, and importantly in the need for improved imaging techniques of the small airways, particularly under standardized conditions that would allow for accurate and sensitive assessment of the extent of airway remodeling, its changes with time (e.g. in aging or asthma in the elderly) or responsiveness to therapies.

Y.S. Prakash
Deputy Editor

Link to the manuscript ; Pascone, CD et al...