Monday, February 13, 2017

Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and non-asthmatics

Airway remodeling is a cardinal feature of diseases such as asthma. Previous measurements and modeling of the airways of non-asthmatics vs. asthmatics have shown that increased airway smooth muscle contributes substantially to remodeling and the resultant narrowing of the airway lumen. However, the assumption in models based on lung morphometry is that narrowing occurs proportionately, i.e. homogenously along the branches of the bronchial tree. In this elegant modeling paper based on measurements of airway lumens from asthmatics vs. non-asthmatics, Pascoe et al. demonstrate for the first time that there is profound heterogeneity in the extent of remodeling along the different branches of the bronchial tree, with small airways contributing particularly to such heterogeneity. The predicted physiological importance of this heterogeneity in airwaywall dimensions of non-asthmatics and asthmatics lies in their contribution to airway hyperresponsiveness (the model predicting a leftward shift in the likely dose response to bronchoconstrictor agonist). Here, closure of small airways is predicted, as is known to occur in obstructive airway disease. However, what is interesting is that a disproportionate or greater heterogeneity in asthmatic airways does not necessarily predict AHR, but it is the increase in airway wall dimensions that does. The appeal of such elegant modeling studies in human lungs of asthmatics vs. non-asthmatics lies in emphasizing the need for more mechanistic studies on remodeling, particularly of the small airways that contribute to premature closure and obstructive disease, and importantly in the need for improved imaging techniques of the small airways, particularly under standardized conditions that would allow for accurate and sensitive assessment of the extent of airway remodeling, its changes with time (e.g. in aging or asthma in the elderly) or responsiveness to therapies.

Y.S. Prakash
Deputy Editor

Link to the manuscript ; Pascone, CD et al...

Thursday, February 9, 2017

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age- 2 related severity of acute lung injury

Why do we age?  In a previous paper, Dr. Hecker demonstrated that imbalance among reactive species, contributed by NOX4 and antioxidant defenses, is a major factor in aging.  In this paper, Dr. Hecker demonstrated that aged mice develop more severe lung injury than younger mice when given LPS and then ventilated (a double hit model of injury).  This mimics what is observed in the clinic, i.e. older people are at a higher risk of ARDS than younger people after trauma.  Dr. Hecker followed up this in vivo observations with in studies on senescent microvascular cells and showed that they suffered significantly higher injury than young endothelial cells when exposed to LPS.  Furthermore, they demonstrated that NOX4 was upregulated in both old (senescent)  and young endothelial cells but in senescent endothelial cells NOX4 was not ubiquinated and thus continue to produce reactive species.  This findings increase our understanding of why we age.  Furthermore, they point out that we all should eat more antioxidants or take more vitamin C

Sadis Matalon

Click here for full paper  http://ajplung.physiology.org/content/early/2017/01/03/ajplung.00305.2016

Wednesday, January 18, 2017

Respiration Section Banquet at Experimental Biology

Dear Respiration Section Members,

The website for purchasing tickets for the Respiration Section Banquet  at Experimental Biology in Chicago, IL is  now live. The dinner will take place on  Monday,  April 24, 2017 from  7:30- 9:30 pm onboard the Odyssey Cruise. Tickets to the Respiration Section Banquet  is quite popular and sells out very quickly. For more information about the banquet, please click on this link http://www.the-aps.org/mm/hp/Audiences/Sections/banquets/Respiration-Section-Banquet.pdf .

Thanks to those  who have already purchased tickets.  For USA Residents, your tickets will be mailed out around the first week of March.  For International Ticket Holders, you will pick up your tickets onsite.  An email will be sent to you around the first week of March with details on where to pick up your tickets at EB17.

Please click on the link below to purchase your tickets today.  Banquet Tickets WILL NOT be sold on board so don’t hesitate, purchase your tickets today.

https://store.the-aps.org/?format=banquethttps://store.the-aps.org/?format=banquet

Ann Marie Bocus
Sections Administrator

Thursday, January 12, 2017

APS-Select January 2016

AJP-Lung is proud to announce that  Dr. Grothausmann and colleagues have had their paper chosen for APSselect this month.




Click on the title to read this exciting study!





Wednesday, December 14, 2016

Best Research Paper published in AJP-Lung by a Junior Investigator

The American Journal of Physiology-Lung Cellular and Molecular Physiology invites nominations for the “Best original research paper published in AJP-Lung between 2014-2016 by a junior author (Assistant Professor, Instructor, Post-doctoral fellow or graduate student.)  The nominee must be either first or senior author and in the opinion of the nominator, contributed significantly in the inception and conduct of this project.  Please submit a nomination stating the importance of this paper in the field as well as the contributions of the first author to Dr. Sadis Matalon, Editor AJP-Lung  (sadis@uab.edu) with a copy to Ms. McEver (amcever@emory.edu) by January 30, 2017.  All applications will be reviewed by the Editor and Associate Editors who will chose the winner by secret ballot.  The winner will receive $500 and a certificate of appreciation at the EB 2017 meeting.

Friday, August 5, 2016

APS-Select August 2016

AJP-Lung was very happy to have a very important article chosen this month for the prestigious APSselect. Click on the title to go directly to the paper

Congratulations go out to:


E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke

Elizabeth M. Martin, Phillip W. Clapp, Meghan E. Rebuli, Erica A. Pawlak, Ellen Glista-Baker, Neal L. Benowitz, Rebecca C. Fry, Ilona Jaspers
 

Thursday, July 21, 2016

Giessen Scholarship Award Winners

AJP-Lung would like to following receipients of our first  travel scholarship to attend Welcome to the 14th Annual Retreat of the International Graduate Programme in Molecular Biology and Medicine of the Lung

Dr. Yoko Ito, National Jewish Health, University of Colorado Denver
and
Dr. Andrea Frump, Indiana University School of Medicine


Please view the link here to view the program: Retreat Programme