Monday, April 24, 2017

Congratulations to the 2016 Paper of the Year Award Winners

It is with great pleasure that we announce the 2016 winners of AJP-Lung's Paper of the Year.  Each will receive $500 and Certificate.

Best Research Paper by a Junior Investigator 

 Dr. Roman Grothausmann

 Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L243-L257. Epub 2016 Dec 2. Digital 3Dreconstructions using histological serial sections of lung tissue including thealveolar capillary network. Grothausmann, R., Knudsen L, Ochs M, Mühlfeld C); PMID: 27913424



Best Research Paper by a Senior Investigator

 Dr. Dean Sheppard

         Am J Physiol Lung Cell Mol Physiol. January 1, 2017 DOI: 10.1152/ajplung.00428.2016. Transforming growth factor-β playsdivergent roles in modulating vascular remodeling, inflammation, and pulmonaryfibrosis in a murine model of scleroderma.Kazuyuki Tsujino, Nilgun Isik Reed, Amha Atakilit, Xin Ren, Dean Sheppard



AJP-Lung Highlights of 2016 Presentation

Please see the updated PowerPoint Presentation below, We are proud of our accomplishments made in the past year at AJP-Lung...

Matalon PPTX Experimental Bio 2017 to Be Posted in Web[1] by ajplung on Scribd

Friday, April 14, 2017

AJP-Lung first quarter submissions are up!

We just received our first quarter numbers for 2017 and are pleased to tell you that AJP-Lung had a 7% increase in submissions over our 1st quarter 2016 (which was our banner year).  Please keep submitting your best work to us!

Tuesday, April 11, 2017

AJP-Lung Highlights of 2016

Dr. Matalon presented the following highlights of AJP-Lung at the Publications meeting in March 2017.  We are very proud to share them with you.

AJP-Lung Matalon 3-21-2017 by ajplung on Scribd

Monday, March 6, 2017

APS Select March 2017

Congratulations go to Dr, Palumbo and collelagues for their recent pick as an APS Select paper for March 2017.

You can read this important paper here :

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Monday, February 13, 2017

Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and non-asthmatics

Airway remodeling is a cardinal feature of diseases such as asthma. Previous measurements and modeling of the airways of non-asthmatics vs. asthmatics have shown that increased airway smooth muscle contributes substantially to remodeling and the resultant narrowing of the airway lumen. However, the assumption in models based on lung morphometry is that narrowing occurs proportionately, i.e. homogenously along the branches of the bronchial tree. In this elegant modeling paper based on measurements of airway lumens from asthmatics vs. non-asthmatics, Pascoe et al. demonstrate for the first time that there is profound heterogeneity in the extent of remodeling along the different branches of the bronchial tree, with small airways contributing particularly to such heterogeneity. The predicted physiological importance of this heterogeneity in airwaywall dimensions of non-asthmatics and asthmatics lies in their contribution to airway hyperresponsiveness (the model predicting a leftward shift in the likely dose response to bronchoconstrictor agonist). Here, closure of small airways is predicted, as is known to occur in obstructive airway disease. However, what is interesting is that a disproportionate or greater heterogeneity in asthmatic airways does not necessarily predict AHR, but it is the increase in airway wall dimensions that does. The appeal of such elegant modeling studies in human lungs of asthmatics vs. non-asthmatics lies in emphasizing the need for more mechanistic studies on remodeling, particularly of the small airways that contribute to premature closure and obstructive disease, and importantly in the need for improved imaging techniques of the small airways, particularly under standardized conditions that would allow for accurate and sensitive assessment of the extent of airway remodeling, its changes with time (e.g. in aging or asthma in the elderly) or responsiveness to therapies.

Y.S. Prakash
Deputy Editor

Link to the manuscript ; Pascone, CD et al...

Thursday, February 9, 2017

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age- 2 related severity of acute lung injury

Why do we age?  In a previous paper, Dr. Hecker demonstrated that imbalance among reactive species, contributed by NOX4 and antioxidant defenses, is a major factor in aging.  In this paper, Dr. Hecker demonstrated that aged mice develop more severe lung injury than younger mice when given LPS and then ventilated (a double hit model of injury).  This mimics what is observed in the clinic, i.e. older people are at a higher risk of ARDS than younger people after trauma.  Dr. Hecker followed up this in vivo observations with in studies on senescent microvascular cells and showed that they suffered significantly higher injury than young endothelial cells when exposed to LPS.  Furthermore, they demonstrated that NOX4 was upregulated in both old (senescent)  and young endothelial cells but in senescent endothelial cells NOX4 was not ubiquinated and thus continue to produce reactive species.  This findings increase our understanding of why we age.  Furthermore, they point out that we all should eat more antioxidants or take more vitamin C

Sadis Matalon

Click here for full paper

Wednesday, January 18, 2017

Respiration Section Banquet at Experimental Biology

Dear Respiration Section Members,

The website for purchasing tickets for the Respiration Section Banquet  at Experimental Biology in Chicago, IL is  now live. The dinner will take place on  Monday,  April 24, 2017 from  7:30- 9:30 pm onboard the Odyssey Cruise. Tickets to the Respiration Section Banquet  is quite popular and sells out very quickly. For more information about the banquet, please click on this link .

Thanks to those  who have already purchased tickets.  For USA Residents, your tickets will be mailed out around the first week of March.  For International Ticket Holders, you will pick up your tickets onsite.  An email will be sent to you around the first week of March with details on where to pick up your tickets at EB17.

Please click on the link below to purchase your tickets today.  Banquet Tickets WILL NOT be sold on board so don’t hesitate, purchase your tickets today.

Ann Marie Bocus
Sections Administrator

Thursday, January 12, 2017

APS-Select January 2016

AJP-Lung is proud to announce that  Dr. Grothausmann and colleagues have had their paper chosen for APSselect this month.

Click on the title to read this exciting study!