The good news: this winter’s wave of flu cases has finally started to decline. The bad news: high-mortality, novel strains of influenza continue to arise (e.g. H7N9), raising the specter of a major pandemic if they acquire greater transmissibility from person-to-person.
A recent online article here discusses the possible use of statins to reduce mortality in a pandemic scenario, and includes comments by one of our AJP-Lung Associate editors, Dr.Lester Kobzik.
AJP-Lung has been contributing to the scientific progress on this topic, with a review and several relevant articles in 2013 alone:
Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-κB andp38 MAPK signaling pathways.
Neonatal hyperoxia alters the host response to influenza A virus infection in adult mice through multiplepathways.
Compromised respiratory function in lethal influenza infection is characterized by the depletion oftype I alveolar epithelial cells beyond threshold levels.
What do you think about this? Care to tell us in the comments?