In an outstanding review which just appeared in AJP-Lung articles in press, Drs. , , and discuss the role of alveolar macrophages in the initiation of the inflammatory response as well as the resolution of injury and enhancement of repair in animal models and patients with Acute Lung Injury.
A very valuable aspect of this review is the comparison and contrast of the regulation of human and murine alveolar macrophages. As my grandfather (or grandmother) used to say “a picture is worth a thousand words). Some of the most important conclusions of this review are summarized in their Figure 1. This is a “must read” review for scientists interested in macrophage immunobiology.