In an outstanding review which just appeared in AJP-Lung articles in press, Drs. , , and discuss the role of alveolar macrophages in the
initiation of the inflammatory response as well as the resolution of injury and
enhancement of repair in animal models and patients with Acute Lung
Injury.
A very valuable aspect of this review is the comparison and
contrast of the regulation of human and murine alveolar macrophages. As
my grandfather (or grandmother) used to say “a picture is worth a thousand
words). Some of the most important conclusions of this review are
summarized in their Figure 1. This is a “must read” review for scientists
interested in macrophage immunobiology.
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