Dysregulated Nox4 ubiquitination contributes to redox imbalance and age- 2 related severity of acute lung injury

Why do we age?  In a previous paper, Dr. Hecker demonstrated that imbalance among reactive species, contributed by NOX4 and antioxidant defenses, is a major factor in aging.  In this paper, Dr. Hecker demonstrated that aged mice develop more severe lung injury than younger mice when given LPS and then ventilated (a double hit model of injury).  This mimics what is observed in the clinic, i.e. older people are at a higher risk of ARDS than younger people after trauma.  Dr. Hecker followed up this in vivo observations with in studies on senescent microvascular cells and showed that they suffered significantly higher injury than young endothelial cells when exposed to LPS.  Furthermore, they demonstrated that NOX4 was upregulated in both old (senescent)  and young endothelial cells but in senescent endothelial cells NOX4 was not ubiquinated and thus continue to produce reactive species.  This findings increase our understanding of why we age.  Furthermore, they point out that we all should eat more antioxidants or take more vitamin C

Sadis Matalon

Click here for full paper  http://ajplung.physiology.org/content/early/2017/01/03/ajplung.00305.2016

Respiration Section Banquet at Experimental Biology

Dear Respiration Section Members,

The website for purchasing tickets for the Respiration Section Banquet  at Experimental Biology in Chicago, IL is  now live. The dinner will take place on  Monday,  April 24, 2017 from  7:30- 9:30 pm onboard the Odyssey Cruise. Tickets to the Respiration Section Banquet  is quite popular and sells out very quickly. For more information about the banquet, please click on this link http://www.the-aps.org/mm/hp/Audiences/Sections/banquets/Respiration-Section-Banquet.pdf .

Thanks to those  who have already purchased tickets.  For USA Residents, your tickets will be mailed out around the first week of March.  For International Ticket Holders, you will pick up your tickets onsite.  An email will be sent to you around the first week of March with details on where to pick up your tickets at EB17.

Please click on the link below to purchase your tickets today.  Banquet Tickets WILL NOT be sold on board so don’t hesitate, purchase your tickets today.

https://store.the-aps.org/?format=banquethttps://store.the-aps.org/?format=banquet

Ann Marie Bocus
Sections Administrator

APS-Select January 2016

AJP-Lung is proud to announce that  Dr. Grothausmann and colleagues have had their paper chosen for APSselect this month.

Click on the title to read this exciting study!

Digital 3D reconstructions using histological serial sections of lung tissue including the alveolar capillary network

Best Research Paper published in AJP-Lung by a Junior Investigator

The American Journal of Physiology-Lung Cellular and Molecular Physiology invites nominations for the “Best original research paper published in AJP-Lung between 2014-2016 by a junior author (Assistant Professor, Instructor, Post-doctoral fellow or graduate student.)  The nominee must be either first or senior author and in the opinion of the nominator, contributed significantly in the inception and conduct of this project.  Please submit a nomination stating the importance of this paper in the field as well as the contributions of the first author to Dr. Sadis Matalon, Editor AJP-Lung  (sadis@uab.edu) with a copy to Ms. McEver (amcever@emory.edu) by January 30, 2017.  All applications will be reviewed by the Editor and Associate Editors who will chose the winner by secret ballot.  The winner will receive $500 and a certificate of appreciation at the EB 2017 meeting.

APS-Select August 2016

AJP-Lung was very happy to have a very important article chosen this month for the prestigious APSselect. Click on the title to go directly to the paper

Congratulations go out to:

E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke

Elizabeth M. Martin, Phillip W. Clapp, Meghan E. Rebuli, Erica A. Pawlak, Ellen Glista-Baker, Neal L. Benowitz, Rebecca C. Fry, Ilona Jaspers

 

American Journal of Physiology - Lung Cellular and Molecular Physiology Published 12 July 2016 Vol. 311 no. 1, L135-L144 DOI: 10.1152/ajplung.00170.2016

Giessen Scholarship Award Winners

AJP-Lung would like to following receipients of our first  travel scholarship to attend Welcome to the 14th Annual Retreat of the International Graduate Programme in Molecular Biology and Medicine of the Lung

Dr. Yoko Ito, National Jewish Health, University of Colorado Denver
and
Dr. Andrea Frump, Indiana University School of Medicine


Please view the link here to view the program: Retreat Programme

AJP-Lung Behind the Scenes

AJP-Lung would like to recognize our excellent team that works behind the scenes to make this the best pulmonary journal published.  Ellyn Kestnbaum is our journal Supervisor who works tirelessly after your paper is accepted until it is published.  Mona Trang  worked for us for many years in the peer review department but has recently retired.  We were very lucky to have Daniel Pisconte come on as our peer review Coordinator.  He is always invaluable in helping out with manuscript submissions.  We are very fortunate to have these individuals on our AJP-Lung team and appreciate them very much.