Call for Papers- Biomarkers in Lung Diseases

Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies

The study of protein, lipid, genetic, and genomic biomarkers of lung disease is an important tool for understanding the biology of human lung disease.  Both candidate biomarker approaches and high dimensional platforms can provide new insights into pathogenesis and confirmation of the clinical relevance of experimental findings.  In recognition of the central role that biomarker research plays in bridging basic and clinical research in human lung disease, the American Journal of Physiology Lung Cellular and Molecular Physiology is issuing a call for papers on the topic of “Biomarkers in Lung Disease: from Pathogenesis to Prediction”. This call for papers requests high-quality studies of human disease biomarkers in patient samples and tissues that enhance our understanding of the pathogenesis of human lung diseases such as Pulmonary Arterial Hypertension, Pulmonary Fibrosis, Acute Lung Injury, COPD, Acute Lung Injury and Lung Cancer. A number of reviews by experts in the field will also be solicited. 

All papers will be reviewed promptly, thoroughly, and fairly by members of the Editorial Board and guest reviewers who are recognized experts in this field. Accepted manuscripts will be published on line within two weeks after acceptance under a distinct heading and will receive special attention and handling. Only those papers not requiring extensive revision will be published under this Highlighted Topic. 

The deadline for this Call for Papers is December 31, 2015

Winner of the “best original research paper published in AJP-Lung between 2012-2014 by a junior author”

The Editor of the American Journal of Physiology-Lung Cellular and Molecular Physiology, solicited nominations for the “best original research paper published in AJP-Lung between 2012-2014 by a junior author” (Assistant Professor, Instructor, Post-doctoral fellow or graduate student.)

We received five nominations and in each case the paper and nominee were truly outstanding.  The selection was made by secret ballot:  All of the Associate Editors of AJP-Lung read the papers and letters of nominations and ranked each nominee from the scale of one (perfect to five.)

The 2015 winner is Dr. Praveen Mannam (nominated by Dr. Patty Lee, from the Pulmonary Division of Yale University) for his paper:

MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced

lung injury.   Mannam P et al.  Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L604-19. doi: 10.1152/ajplung.00272.2013. Epub 2014 Jan 31.

In his paper, Praveen identified for the first time MKK3 as a potential therapeutic target in sepsis. He used complementary murine models of sepsis (LPS and cecal ligation puncture) and confirmed his findings in circulating cells from septic patients to demonstrate that the deleterious effect of over-activated MKK3 in sepsis is through its effects on mitochondrial protein Pink1. Prior to these studies, a MKK3-mitochondria link had not been described and Pink1 had been reported primarily in neuronal tissue. These studies have led to partnerships with Yale Small Molecule Center and Evotec, a drug-discovery company, which have yielded first-in-class MKK3 small molecule inhibitors that Praveen is now in the process of testing in experimental sepsis models.  Praveen is currently an Assistant Professor in the Section of Pulmonary, Critical Care & Sleep Medicine at Yale University

This article is one of our featured articles in the AJP-Lung Website (http://ajplung.physiology.org)

and was also chosen for inclusion by the APS Publications committee in APSselect http://apsselect.physiology.org/archives-2014#january-february; May 2014 issue)

Dr. Mannam will receive $500 and a certificate of appreciation at the EB 2015 meeting following the Comroe Lecture (Tuesday, March 31 at 10:30 AM Room 210A)

New Associate Editor: Dr. Larrisa Shimoda

I am very pleased to announce that Dr. Larissa Shimoda became an Associate Editor for AJP-Lung effective January 1^st, 2015.  

  Larissa Shimoda is an Associate Professor of Medicine in the Division of Pulmonary and Critical Care Medicine at the Johns Hopkins University School of Medicine. Dr. Shimoda received her BS, MS and PhD degrees in Biomedical Engineering from Marquette University and received postgraduate training in Pulmonary Physiology in the Division of Pulmonary and Critical Care Medicine at Johns Hopkins. 

Dr. Shimoda’s research focuses on His research aims to integrate basic research on intracellular signaling and intercellular communication pathways to the level of the intact organ and organism. His publications have provided significant new insight into the mechanisms contributing to the pathophysiology of acute lung injury, lung edema, and pulmonary hypertension. In the best tradition of translational science, he aims to apply this knowledge for the development and preclinical testing of new therapeutic strategies for the treatment of these diseases.
Dr. Küebler has been a member of the AJP-Lung Editorial Board since 1999 and is currently the Chairman of the Respiration Section of the American Physiological Society. His research aims to integrate basic research on intracellular signaling and intercellular communication pathways to the level of the intact organ and organism. His publications have provided significant new insight into the mechanisms contributing to the pathophysiology of acute lung injury, lung edema, and pulmonary hypertension. In the best tradition of translational science, he aims to apply this knowledge for the development and preclinical testing of new therapeutic strategies for the treatment of these diseases.
Dr. Küebler has been a member of the AJP-Lung Editorial Board since 1999 and is currently the Chairman of the Respiration Section of the American Physiological Society. His research aims to integrate basic research on intracellular signaling and intercellular communication pathways to the level of the intact organ and organism. His publications have provided significant new insight into the mechanisms contributing to the pathophysiology of acute lung injury, lung edema, and pulmonary hypertension. In the best tradition of translational science, he aims to apply this knowledge for the development and preclinical testing of new therapeutic strategies for the treatment of these diseases.
Dr. Küebler has been a member of the AJP-Lung Editorial Board since 1999 and is currently the Chairman of the Respiration Section of the American Physiological Society. the cellular mechanisms involved in the pathogenesis of pulmonary hypertension. She has a keen interest in cellular responses to both acute and prolonged hypoxia and the role of the transcription factor, hypoxia-inducible factor 1, in the lung vasculature.  Dr, Shimoda has been a member of the AJP-Lung Editorial Board since 2006 and is currently the Chair of the Respiration Section of the APS.

 

Sadis Matalon, Editor-in-Chief,

American Journal of Physiology-Lung Cellular and Molecular Physiology