Scholarship available to attend international pulmonary meeting in Germany: Nominations Due

WIN A SCHOLARSHIP TO ATTEND ONE OF THE MOST PRESTIGIOUS PULMONARY MEETINGS IN THE WORLD 

Nominations due by June 21, 2017

Editor in Chief elect of AJP-Lung, Dr. Rory Morty, heads the International Graduate Programme in Molecular Biology and Medicine of the Lung at the Universities  of Giessen and Marburg Lung Center, Germany.  This program sponsors a yearly retreat, which is one of the best pulmonary meetings in the world

We feel that trainees and junior faculty will benefit greatly by attending this meeting to be  held in Rauischholzhausen, Germany July 12-14, 2017.  The American Journal of Physiology-Lung Cellular and Molecular Physiology and the International Graduate Programme Molecular Biology and Medicine of the Lung are co-sponsoring two fellowships this year to allow one trainee (graduate student, post-doctoral fellow or clinical Fellow) and one junior faculty (instructor or Assistant Professor) to travel to Giessen and participate in this meeting.  A travel allowance of up to $1200 to cover transportation will be paid by AJP-Lung while local transportation, food and lodging will be provide the ICPMBM).  Candidates should have published an outstanding paper in AJP-Lung during the last two years as first author while either a trainee or an Assistant Professor.  Those that receive an award from AJP-Lung will be given priority.  Nominations or self-nominations should be sent to the Managing Editor (Ms. Amy McEver at amcever@emory.edu).  Winners will be expected to write a short review on a topic of a lecture by an invited speaker to be considered for publication in AJP-Lung.

 

Rory Morty, PhD                                                      Sadis Matalon, PhD

Deputy Editor

Editor in Chief elect                                                Editor in Chief

APS Select May 2017

We would like to congratulate Dr. O'Neill and his colleagues for having their most recent paper recognized by APS to be one of the best recently published articles in physiological research, this month.

You can read their work here:

The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma

Congratulations to the 2016 Paper of the Year Award Winners

It is with great pleasure that we announce the 2016 winners of AJP-Lung's Paper of the Year.  Each will receive $500 and Certificate.

Best Research Paper by a Junior Investigator 

 Dr. Roman Grothausmann

 Am J Physiol Lung Cell Mol Physiol. 2017 Feb 1;312(2):L243-L257. Epub 2016 Dec 2. Digital 3Dreconstructions using histological serial sections of lung tissue including thealveolar capillary network. Grothausmann, R., Knudsen L, Ochs M, Mühlfeld C); PMID: 27913424

 

 

Best Research Paper by a Senior Investigator

 Dr. Dean Sheppard

         Am J Physiol Lung Cell Mol Physiol. January 1, 2017 DOI: 10.1152/ajplung.00428.2016. Transforming growth factor-β playsdivergent roles in modulating vascular remodeling, inflammation, and pulmonaryfibrosis in a murine model of scleroderma.Kazuyuki Tsujino, Nilgun Isik Reed, Amha Atakilit, Xin Ren, Dean Sheppard

 

 

AJP-Lung Highlights of 2016 Presentation

Please see the updated PowerPoint Presentation below, We are proud of our accomplishments made in the past year at AJP-Lung...

Matalon PPTX Experimental Bio 2017 to Be Posted in Web[1] by ajplung on Scribd

AJP-Lung welcomes our new Editor in Chief, January 1, 2018

AJP-Lung first quarter submissions are up!

We just received our first quarter numbers for 2017 and are pleased to tell you that AJP-Lung had a 7% increase in submissions over our 1st quarter 2016 (which was our banner year).  Please keep submitting your best work to us!

AJP-Lung Highlights of 2016

Dr. Matalon presented the following highlights of AJP-Lung at the Publications meeting in March 2017.  We are very proud to share them with you.




AJP-Lung Matalon 3-21-2017 by ajplung on Scribd

APS Select March 2017

Congratulations go to Dr, Palumbo and collelagues for their recent pick as an APS Select paper for March 2017.

You can read this important paper here :

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury

Heterogeneity of airway wall dimensions in humans: a critical determinant of lung function in asthmatics and non-asthmatics

Airway remodeling is a cardinal feature of diseases such as asthma. Previous measurements and modeling of the airways of non-asthmatics vs. asthmatics have shown that increased airway smooth muscle contributes substantially to remodeling and the resultant narrowing of the airway lumen. However, the assumption in models based on lung morphometry is that narrowing occurs proportionately, i.e. homogenously along the branches of the bronchial tree. In this elegant modeling paper based on measurements of airway lumens from asthmatics vs. non-asthmatics, Pascoe et al. demonstrate for the first time that there is profound heterogeneity in the extent of remodeling along the different branches of the bronchial tree, with small airways contributing particularly to such heterogeneity. The predicted physiological importance of this heterogeneity in airwaywall dimensions of non-asthmatics and asthmatics lies in their contribution to airway hyperresponsiveness (the model predicting a leftward shift in the likely dose response to bronchoconstrictor agonist). Here, closure of small airways is predicted, as is known to occur in obstructive airway disease. However, what is interesting is that a disproportionate or greater heterogeneity in asthmatic airways does not necessarily predict AHR, but it is the increase in airway wall dimensions that does. The appeal of such elegant modeling studies in human lungs of asthmatics vs. non-asthmatics lies in emphasizing the need for more mechanistic studies on remodeling, particularly of the small airways that contribute to premature closure and obstructive disease, and importantly in the need for improved imaging techniques of the small airways, particularly under standardized conditions that would allow for accurate and sensitive assessment of the extent of airway remodeling, its changes with time (e.g. in aging or asthma in the elderly) or responsiveness to therapies.

Y.S. Prakash
Deputy Editor

Link to the manuscript ; Pascone, CD et al...

Dysregulated Nox4 ubiquitination contributes to redox imbalance and age- 2 related severity of acute lung injury

Why do we age?  In a previous paper, Dr. Hecker demonstrated that imbalance among reactive species, contributed by NOX4 and antioxidant defenses, is a major factor in aging.  In this paper, Dr. Hecker demonstrated that aged mice develop more severe lung injury than younger mice when given LPS and then ventilated (a double hit model of injury).  This mimics what is observed in the clinic, i.e. older people are at a higher risk of ARDS than younger people after trauma.  Dr. Hecker followed up this in vivo observations with in studies on senescent microvascular cells and showed that they suffered significantly higher injury than young endothelial cells when exposed to LPS.  Furthermore, they demonstrated that NOX4 was upregulated in both old (senescent)  and young endothelial cells but in senescent endothelial cells NOX4 was not ubiquinated and thus continue to produce reactive species.  This findings increase our understanding of why we age.  Furthermore, they point out that we all should eat more antioxidants or take more vitamin C

Sadis Matalon

Click here for full paper  http://ajplung.physiology.org/content/early/2017/01/03/ajplung.00305.2016

Respiration Section Banquet at Experimental Biology

Dear Respiration Section Members,

The website for purchasing tickets for the Respiration Section Banquet  at Experimental Biology in Chicago, IL is  now live. The dinner will take place on  Monday,  April 24, 2017 from  7:30- 9:30 pm onboard the Odyssey Cruise. Tickets to the Respiration Section Banquet  is quite popular and sells out very quickly. For more information about the banquet, please click on this link http://www.the-aps.org/mm/hp/Audiences/Sections/banquets/Respiration-Section-Banquet.pdf .

Thanks to those  who have already purchased tickets.  For USA Residents, your tickets will be mailed out around the first week of March.  For International Ticket Holders, you will pick up your tickets onsite.  An email will be sent to you around the first week of March with details on where to pick up your tickets at EB17.

Please click on the link below to purchase your tickets today.  Banquet Tickets WILL NOT be sold on board so don’t hesitate, purchase your tickets today.

https://store.the-aps.org/?format=banquethttps://store.the-aps.org/?format=banquet

Ann Marie Bocus
Sections Administrator

APS-Select January 2016

AJP-Lung is proud to announce that  Dr. Grothausmann and colleagues have had their paper chosen for APSselect this month.

Click on the title to read this exciting study!

Digital 3D reconstructions using histological serial sections of lung tissue including the alveolar capillary network